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Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $43 | 5 days |
Description | DS-437 is a dual PRMT5/7 inhibitor with IC50 values of 6 μM and also inhibits DNMT3A and DNMT3B with IC50 values of 52 μM and 62 μM, respectively. Additionally, DS-437 inhibits the methylation of FOXP3. |
In vitro | DS-437 increased total CD8+?and CD8+ PD-1+ T cells [2]. DS-437 was able to inhibit the methylation of an H4[1–24] peptide by the PRMT5–MEP50 complex under balanced conditions (cofactor and substrate concentrations set at their respective?Km?values) in a dose-dependent manner (IC50: 5.9 μM) [1]. |
In vivo | The combination of DS-437 and the anti-p185erbB2/neu?antibody 4D5 had even more dramatic effects. DS-437 (10 mg/kg; i.p.; 5 times a week) has some beneficial effects on inhibiting tumor growth [1]. |
Molecular Weight | 397.45 |
Formula | C15H23N7O4S |
Cas No. | 1674364-87-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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