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DU-14 (PTP1B/TC-PTP PROTAC)

Name: DU-14 (PTP1B/TC-PTP PROTAC)
Brand: TargetMol
SKU: T203548
Rating: 4.5 (1 reviews)

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Catalog No. T203548Cas No. 3053413-58-1

DU-14 (PTP1B/TC-PTPPROTAC) is a potent and selective dual PROTAC degrader for PTP1B and TC-PTP, exhibiting IC50 values of 24.2 nM and 30.1 nM for the phosphatase activity of PTP1B and TC-PTP, respectively. It enhances IFN-γ signaling, promotes T cell activation, and possesses antitumor activity.

DU-14 (PTP1B/TC-PTP PROTAC)

😃Good

Catalog No. T203548Cas No. 3053413-58-1

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Product Introduction

Bioactivity

Description	DU-14 (PTP1B/TC-PTPPROTAC) is a potent and selective dual PROTAC degrader for PTP1B and TC-PTP, exhibiting IC50 values of 24.2 nM and 30.1 nM for the phosphatase activity of PTP1B and TC-PTP, respectively. It enhances IFN-γ signaling, promotes T cell activation, and possesses antitumor activity.
In vitro	DU-14 (PTP1B/TC-PTP PROTAC) (0-1000 nM; 16 hours) induces degradation of PTP1B/TC-PTP and enhances STAT1 phosphorylation in IFN-γ-treated MC38 cells.
In vivo	In a mouse model of colon cancer, DU-14 (PTP1B/TC-PTP PROTAC) demonstrates antitumor activity when administered via intraperitoneal injection at a dosage of 25-50 mg/kg over 10 days.

Chemical Properties

Molecular Weight	1505.46
Formula	C₇₄H₈₅BrF₂N₉O₁₄PS
Cas No.	3053413-58-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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