Shopping Cart
- Remove All
![TargetMol](https://www.targetmol.com/storage/error/oops.webp)
Your shopping cart is currently empty
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $76 | Backorder | |
5 mg | $340 | Backorder | |
10 mg | $588 | Backorder | |
25 mg | $1,220 | Backorder |
Description | E70K is a compound that inhibits the interaction between the chemokine (C-X-C) ligand 8 (CXCL8) and glycosaminoglycans (GAGs) on cell membrane surfaces. It mimics a segment of the CXCL8 protein's GAG-binding region at the C-terminal end, incorporating a glutamate-to-lysine mutation at the 70th position. At a concentration of 50 nM, E70K notably reduces the attachment of primary human neutrophils to human umbilical vein endothelial cells (HUVECs). Moreover, it impedes the CXCL8-triggered movement of these neutrophils across HMEC-1 human microvascular endothelial cell layers within a concentration range of 1 to 1,000 nM. |
Molecular Weight | 2400.80 |
Formula | C108H178N34O28.XCF3COOH |
Cas No. |
Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
Solubility Information | PBS pH 7.2: 2 mg/ml DMSO: 10 mg/ml |
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.