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EC0489

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Catalog No. T13672Cas No. 1096702-14-5

EC0489 is a small molecule-drug conjugate (SMDC) that combines folic acid and desacetyl vinblastine hydrazide, serving as a high-affinity ligand for the folate receptor (FR) in refractory or metastatic tumors.

EC0489

EC0489

😃Good
Catalog No. T13672Cas No. 1096702-14-5
EC0489 is a small molecule-drug conjugate (SMDC) that combines folic acid and desacetyl vinblastine hydrazide, serving as a high-affinity ligand for the folate receptor (FR) in refractory or metastatic tumors.
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Product Introduction

Bioactivity
Description
EC0489 is a small molecule-drug conjugate (SMDC) that combines folic acid and desacetyl vinblastine hydrazide, serving as a high-affinity ligand for the folate receptor (FR) in refractory or metastatic tumors.
In vitro
FR-positive KB cells are highly sensitive to EC0489 with an IC50 of 5 nM.The affinity of EC0489 toward the folate receptor (FR) is approximately half of that of folic acid (relative affinity 0.50).
In vivo
EC0489, administered at doses of 2, 3, and 4 μmol/kg, exhibits dose-dependent antitumor activity in mouse KB tumor models. Furthermore, EC0489 demonstrates a favorable toxicology profile in rats.
Chemical Properties
Molecular Weight2550.7
FormulaC111H156N22O43S2
Cas No.1096702-14-5
Relative Density.1.66 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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