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EMI48

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Catalog No. T61179Cas No. 34564-13-1

EMI48, a derivative of EMI1, exhibits increased efficacy against mutant EGFR compared to EMI1. It specifically inhibits EGFR triple mutants [1].

EMI48

EMI48

😃Good
Catalog No. T61179Cas No. 34564-13-1
EMI48, a derivative of EMI1, exhibits increased efficacy against mutant EGFR compared to EMI1. It specifically inhibits EGFR triple mutants [1].
Pack SizePriceAvailabilityQuantity
5 mg$2596-8 weeks
25 mg$8936-8 weeks
50 mg$1,1606-8 weeks
100 mg$1,6506-8 weeks
1 mL x 10 mM (in DMSO)$2726-8 weeks
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Product Introduction

Bioactivity
Description
EMI48, a derivative of EMI1, exhibits increased efficacy against mutant EGFR compared to EMI1. It specifically inhibits EGFR triple mutants [1].
In vitro
EMI48 effectively targets and inhibits the EGFR ex19del/T790M/C797S and EGFR L858R/T790M/C797S mutations, making it a valuable agent in the study of mutant EGFR-associated, drug-resistant non-small-cell lung cancer (NSCLC) [1].
Chemical Properties
Molecular Weight348.4
FormulaC21H20N2O3
Cas No.34564-13-1
Storage & Solubility Information
StorageShipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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