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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $168 | 35 days | |
5 mg | $690 | 35 days | |
10 mg | $1,320 | 35 days |
Description | EP4 antagonist 14 is a prostaglandin E2 receptor subtype EP4 antagonist, demonstrating an IC50 of 1.1 nM in a HEK293 human receptor reporter assay and blocking β-arrestin recruitment due to PGE2 with an IC50 of 0.9 nM. At 10 µM, it reduces PGE2-stimulated mRNA levels of Il-4, macrophage mannose receptor 1 (Mrc1), chitinase-like protein 3 (Chil3), chemokine (C-X-C) motif ligand 1 (Cxcl1), triggering receptor expressed on myeloid cells 2 (Trem2), and arginase-1 (Arg1) in RAW 264.7 macrophages. When used at 30 mg/kg per day alongside anti-PD-1 antibodies, it curbs tumor growth and enhances CD8+ T cell infiltration in tumors using a CT26 murine colon cancer model. |
Alias | Prostaglandin E2 Receptor 4 Antagonist 14, PGE2 Receptor 4 Antagonist 14 |
Molecular Weight | 453.41 |
Formula | C24H18F3N3O3 |
Cas No. |
Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
Solubility Information | DMF: 20 mg/ml DMSO: 20 mg/ml |
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