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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $59 | Backorder | |
5 mg | $229 | Backorder | |
10 mg | $336 | Backorder | |
25 mg | $685 | Backorder |
Description | EPI-X4, an endogenous peptide fragment of human serum albumin (amino acids 408-423), serves as an antagonist to the chemokine (C-X-C motif) receptor 4 (CXCR4). It effectively prevents calcium mobilization and receptor internalization triggered by chemokine (C-X-C motif) ligand 12 (CXCL12) in HEK293 cells with CXCR4 expression, at concentrations between 0.8 and 1,000 µM. Moreover, EPI-X4 hampers the CXCL12-driven migration of both Jurkat T cells and human CD34+ hematopoietic stem cells. In an acute allergic airway hypereosinophilia mouse model, EPI-X4 intrinsically decreases Cxcr4-dependent inflammatory cell infiltration in airways at a dose of 16 µmol/kg. Additionally, increased urinary EPI-X4 levels, inversely related to glomerular filtration rate (GFR), are observed in chronic kidney disease patients, indicating its potential biomarker role. |
Alias | Endogenous Peptide Inhibitor of CXCR4 |
Molecular Weight | 1830.18 |
Formula | C84H144N22O23.XCF3COOH |
Cas No. |
Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
Solubility Information | Ethanol: Soluble Methanol: Soluble |
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