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ERD03

Name: ERD03
Brand: TargetMol
SKU: T61072
Price: 163 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T61072Cas No. 1377897-01-2

Alias ERD 03

ERD03 is a selective compound targeting EXOSC3, disrupting EXOSC3-RNA interactions in a concentration-dependent manner, useful in brain neurodegenerative disease research.

ERD03

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Purity: 100%

Catalog No. T61072Alias ERD 03Cas No. 1377897-01-2

ERD03 is a selective compound targeting EXOSC3, disrupting EXOSC3-RNA interactions in a concentration-dependent manner, useful in brain neurodegenerative disease research.

Pack Size	Price	Availability
1 mg	$163	In Stock
5 mg	$397	In Stock
10 mg	$652	In Stock
25 mg	$1,280	In Stock
1 mL x 10 mM (in DMSO)	$449	In Stock

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Purity:100%

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COA HNMR HPLC LCMS

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	ERD03 is a selective compound targeting EXOSC3, disrupting EXOSC3-RNA interactions in a concentration-dependent manner, useful in brain neurodegenerative disease research.
In vitro	Methods: ERD03 (50 μM) was incubated with EXOSC3 and several concentrations of long G-rich RNA. The effect of ERD03 on the RNA/EXOSC3 interaction was tested using MST to measure the inhibitory effect of ERD03. Results: ERD03 reduced the binding of EXOSC3 to long G-rich RNA at several RNA concentrations; at 3.1 μM RNA, ERD03 inhibited the binding by 54%, in a concentration-dependent manner and similar inhibition was observed with long G-rich RNA. [1]
Alias	ERD 03

Chemical Properties

Molecular Weight	339.43
Formula	C₂₁H₂₅NO₃
Cas No.	1377897-01-2
Smiles	O=C(C1=CC=CC(=C1)CCC(O)(C)C)N2CC=3C=CC=CC3C(O)C2

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 80 mg/mL (235.69 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9461 mL	14.7306 mL	29.4612 mL	147.3058 mL
5 mM	0.5892 mL	2.9461 mL	5.8922 mL	29.4612 mL
10 mM	0.2946 mL	1.4731 mL	2.9461 mL	14.7306 mL
20 mM	0.1473 mL	0.7365 mL	1.4731 mL	7.3653 mL
50 mM	0.0589 mL	0.2946 mL	0.5892 mL	2.9461 mL
100 mM	0.0295 mL	0.1473 mL	0.2946 mL	1.4731 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc