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EZ-482
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Catalog No. T15265Cas No. 1016456-76-0
EZ-482 is a novel ligand of apolipoprotein (apoE). EZ-482 binds to apoE4 by a unique N-terminal allosteric effect and it also binds to sites on apoE in the C-terminal domain (Kds: 5-10 μM for apoE3 and apoE4).
EZ-482
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Catalog No. T15265Cas No. 1016456-76-0
EZ-482 is a novel ligand of apolipoprotein (apoE). EZ-482 binds to apoE4 by a unique N-terminal allosteric effect and it also binds to sites on apoE in the C-terminal domain (Kds: 5-10 μM for apoE3 and apoE4).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $116 | 5 days | |
| 50 mg | $789 | 6-8 weeks | |
| 100 mg | $1,320 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | EZ-482 is a novel ligand of apolipoprotein (apoE). EZ-482 binds to apoE4 by a unique N-terminal allosteric effect and it also binds to sites on apoE in the C-terminal domain (Kds: 5-10 μM for apoE3 and apoE4). |
| Targets&IC50 | ApoE3/ApoE4:（kd）5-10 μM |
| In vitro | EZ-482 (0.5, 1, 5, 10 μM; 1 hour) blocks heparin-binding in a concentration-dependent manner. EZ-482 binds to sites on apoE in the C-terminal domain encompassing residues 229-243 and 258-265. |
| Molecular Weight | 498.94 |
| Formula | C23H19ClN4O5S |
| Cas No. | 1016456-76-0 |
| Relative Density. | 1.49 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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