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EZH2-IN-5

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Catalog No. T38827Cas No. 1403258-69-4
Alias EZH2-IN-5

EZH2-IN-5 is a highly effective inhibitor of EZH2, displaying remarkable potency against both wild-type and mutant Tyr641 EZH2, with IC50 values of 1.52 nM and 4.07 nM, respectively.

EZH2-IN-5

EZH2-IN-5

😃Good
Catalog No. T38827Alias EZH2-IN-5Cas No. 1403258-69-4
EZH2-IN-5 is a highly effective inhibitor of EZH2, displaying remarkable potency against both wild-type and mutant Tyr641 EZH2, with IC50 values of 1.52 nM and 4.07 nM, respectively.
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5 mg$970Backorder
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Product Introduction

Bioactivity
Description
EZH2-IN-5 is a highly effective inhibitor of EZH2, displaying remarkable potency against both wild-type and mutant Tyr641 EZH2, with IC50 values of 1.52 nM and 4.07 nM, respectively.
Targets&IC50
EZH2 (WT):1.52 nM (IC50), EZH2 (Y641F):4.07 nM (IC50)
In vitro
EZH2-IN-5 (compound 276) effectively suppresses the proliferation of WSUDLCL2 cell lines, with an inhibitory concentration (IC50) of 187.28 nM[1].
AliasEZH2-IN-5
Chemical Properties
Molecular Weight517.512
FormulaC26H37BrN4O2
Cas No.1403258-69-4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

EZH2 IN 5EZH-2-IN-5EZH2IN5
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