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FAK inhibitor 5
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Catalog No. T11261Cas No. 1426683-30-8
FAK inhibitor 5 is a novel allosteric FAK inhibitor, with IC50 values in the low micromolar range.
FAK inhibitor 5
😃Good
Catalog No. T11261Cas No. 1426683-30-8
FAK inhibitor 5 is a novel allosteric FAK inhibitor, with IC50 values in the low micromolar range.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | 6-8 weeks | |
| 50 mg | $1,980 | 6-8 weeks | |
| 100 mg | $2,500 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | FAK inhibitor 5 is a novel allosteric FAK inhibitor, with IC50 values in the low micromolar range. |
| Targets&IC50 | FAK (pre-incubation 5 min ATP 1000 μM): 3.0 μM , FAK (pre-incubation 5 min ATP 0.5 μM):1.6 μM , FAK (pre-incubation 60 min ATP 1000 μM): 1.0 μM , FAK (pre-incubation 60 min ATP 0.5 μM): 1.3 μM |
| In vitro | The binding interactions of FAK inhibitor 5 at the FAK allosteric site are primarily hydrophobic. The exposure of the allosteric pocket, caused by the notable movement of Ile547, is accompanied by a similar movement of Arg550 towards the allosteric binding site, where it associates with the tricyclic core of [compounds 2]. |
| Molecular Weight | 367.46 |
| Formula | C20H21N3O2S |
| Cas No. | 1426683-30-8 |
| Relative Density. | 1.29 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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