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Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $72 | 5 days |
Description | Fanapanel hydrate is a highly selective antagonist of AMPA/kainate with little activity against NMDA(Ki of 3.2 nM, 100 nM, and 8.5 μM against quisqualate, kainate, and NMDA, respectively). |
In vivo | In mice, ZK200775 elevated the threshold for AMPA- and kainate-induced clonic seizures with a THRD50 (threshold dose) of 2.9 (1.7–4.6) and 1.6 (1.3–2.0) mg/kg i.v., whereas the threshold for NMDA-induced seizures was elevated only in doses, THRD50 of 24.1 (21.9–26.5) mg/kg i.v., which affected motor coordination in the rotating rod, ED50 14.6 (12.1–17.6) mg/kg. The doses of ZK200775 are 10 and 30 mg/kg (intravenously). Reduced muscle tone in hereditary spastic rats [1]. ZK200775 (3.0 but not 1.5 or 6.0 mg/kg) significantly reduced nicotine-induced (0.6 mg/kg) DA release in NACC and nicotine-stimulated LMA.ZK200775 (1.5, 3.0, 6.0 mg/kg) alone influenced neither DA release nor LMA. ZK200775 showed 34-fold selectivity for AMPA receptors compared to NMDA receptors and no affinity to nicotine receptors [2]. |
Alias | MPQX hydrate, ZK200775 (hydrate) |
Molecular Weight | 427.27 |
Formula | C14H17F3N3O7P |
Cas No. | 1255517-78-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||
Solubility Information | DMSO: 5 mg/mL (11.70 mM) | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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