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FAPy-adenine
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Catalog No. T19320Cas No. 5122-36-1
FAPy-adenine, an oxidized DNA base, is increasingly found in the brains of people with Alzheimer's disease. Nucleoside oxidation, including that of adenine, serves as a biochemical marker for tumors, senescence, and neurodegenerative diseases.
FAPy-adenine
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Catalog No. T19320Cas No. 5122-36-1
FAPy-adenine, an oxidized DNA base, is increasingly found in the brains of people with Alzheimer's disease. Nucleoside oxidation, including that of adenine, serves as a biochemical marker for tumors, senescence, and neurodegenerative diseases.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $35 | 5 days | |
| 5 mg | $54 | 7-10 days | |
| 1 mL x 10 mM (in DMSO) | $89 | 7-10 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | FAPy-adenine, an oxidized DNA base, is increasingly found in the brains of people with Alzheimer's disease. Nucleoside oxidation, including that of adenine, serves as a biochemical marker for tumors, senescence, and neurodegenerative diseases. |
| In vitro | In the absence of the external field the FAPy-adenine is able to form pairs with all four canonical nucleic acid bases.?In contrast, in the presence of the external field the mispairing abilities of FAPy-adenine become insignificant since the most stable dimers are formed with thymine |
| In vivo | Oxygen-derived radicals exacerbate nuclear DNA damage in Alzheimer's disease, reinforcing the notion that the brain endures heightened oxidative stress in this condition. |
| Molecular Weight | 153.14 |
| Formula | C5H7N5O |
| Cas No. | 5122-36-1 |
| Relative Density. | 1.575 g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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