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FEN1-IN-2

Name: FEN1-IN-2
Brand: TargetMol
SKU: T40931
Price: 95 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T40931Cas No. 824983-94-0

FEN1-IN-2 is a selective and potent inhibitor of flap endonuclease 1 (FEN1), inhibits FEN1 and XPG, has potential anticancer activity, and can be used to study DNA damage repair.

FEN1-IN-2

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Purity: 99.92%

Catalog No. T40931Cas No. 824983-94-0

FEN1-IN-2 is a selective and potent inhibitor of flap endonuclease 1 (FEN1), inhibits FEN1 and XPG, has potential anticancer activity, and can be used to study DNA damage repair.

Pack Size	Price	Availability
2 mg	$95	In Stock
5 mg	$156	7-10 days
10 mg	$247	7-10 days
25 mg	$496	7-10 days
50 mg	$787	7-10 days
100 mg	$1,230	7-10 days
500 mg	$2,480	7-10 days
1 mL x 10 mM (in DMSO)	$173	7-10 days

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Purity:99.92%

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COA HNMR LCMS

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Product Introduction

Bioactivity

Description	FEN1-IN-2 is a selective and potent inhibitor of flap endonuclease 1 (FEN1), inhibits FEN1 and XPG, has potential anticancer activity, and can be used to study DNA damage repair.
Targets&IC50	FEN1:3 nM, XPG:226 nM

Chemical Properties

Molecular Weight	393.42
Formula	C₂₀H₁₅N₃O₄S
Cas No.	824983-94-0
Smiles	O=C(N)C1=CC=C(C=C1)C=2C=CC=C(C2)CN3C(=O)N(O)C(=O)C=4SC=CC43

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 80 mg/mL (203.35 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5418 mL	12.7091 mL	25.4181 mL	127.0906 mL
5 mM	0.5084 mL	2.5418 mL	5.0836 mL	25.4181 mL
10 mM	0.2542 mL	1.2709 mL	2.5418 mL	12.7091 mL
20 mM	0.1271 mL	0.6355 mL	1.2709 mL	6.3545 mL
50 mM	0.0508 mL	0.2542 mL	0.5084 mL	2.5418 mL
100 mM	0.0254 mL	0.1271 mL	0.2542 mL	1.2709 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

flap endonuclease 1 (FEN1)FEN1-IN-2FEN-1-IN-2FEN1IN2FEN1 IN 2