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FK-448 Free base
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Catalog No. T11290Cas No. 85858-76-0
FK-448 Free base is a potent and specific chymotrypsin inhibitor, with an IC50 of 720 nM.
FK-448 Free base
😃Good
Catalog No. T11290Cas No. 85858-76-0
FK-448 Free base is a potent and specific chymotrypsin inhibitor, with an IC50 of 720 nM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | 6-8 weeks | |
| 50 mg | $1,980 | 6-8 weeks | |
| 100 mg | $2,500 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | FK-448 Free base is a potent and specific chymotrypsin inhibitor, with an IC50 of 720 nM. |
| Targets&IC50 | Chymotrypsin:720 nM |
| In vitro | FK-448 Free base slightly inhibits esterolysis of Trypsin and Thrombin, with IC50s of 780 and 35 μM, respectively, but shows no effects on esterolysis of plasmin, plasma kallikrein or pancreas kallikrein, with IC50s of all >1 mM. FK-448 moderately inhibits hydrolytic activities of cathepsin G with an IC50 of 15 μM. FK-448 Free base is an effective and specific inhibitor of chymotrypsin, with an IC50 of 720 nM. |
| In vivo | FK-448, administered orally (p.o.) at a dose of 20 mg/kg, not only reduces the blood glucose level but also elevates the plasma Insulin Release Inhibitor (IRI) level in dogs. Meanwhile, when delivered intraperitoneally (i.p.) at the same dosage, FK-448 leads to a decreased blood glucose level and prevents the breakdown of insulin by pancreatic enzymes in rats. |
| Molecular Weight | 406.52 |
| Formula | C25H30N2O3 |
| Cas No. | 85858-76-0 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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