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Fmoc-Ala-Glu-Asn-Lys-NH2

Name: Fmoc-Ala-Glu-Asn-Lys-NH2
Brand: TargetMol
SKU: T38116
Price: 50 USD
Availability: InStock
Rating: 4.5 (1 reviews)

Catalog No. T38116Cas No. 220701-06-4

Alias Fmoc-Ala-Glu-Asn-Lys-NH2

Fmoc-Ala-Glu-Asn-Lys-NH2 is a peptide inhibitor that selectively targets asparagine endopeptidase (AEP) and inhibits the cleavage of amyloid precursor protein (APP). AEP, a pH-controlled cysteine proteinase, plays a crucial role in the proteolytic processing of APP, and its activity is enhanced during the aging process [1].

Fmoc-Ala-Glu-Asn-Lys-NH2

Catalog No. T38116Alias Fmoc-Ala-Glu-Asn-Lys-NH2Cas No. 220701-06-4

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Product Introduction

Bioactivity

Description	Fmoc-Ala-Glu-Asn-Lys-NH2 is a peptide inhibitor that selectively targets asparagine endopeptidase (AEP) and inhibits the cleavage of amyloid precursor protein (APP). AEP, a pH-controlled cysteine proteinase, plays a crucial role in the proteolytic processing of APP, and its activity is enhanced during the aging process [1].
In vitro	Fmoc-Ala-Glu-Asn-Lys-NH2 antagonizes APP processing by AEP, unlike other small molecule inhibitors and the inactive peptide AEQK, which showed no effect [1].
Alias	Fmoc-Ala-Glu-Asn-Lys-NH2

Chemical Properties

Molecular Weight	681.747
Formula	C₃₃H₄₃N₇O₉
Cas No.	220701-06-4

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 100 mg/mL (146.68 mM), Sonication and heating to 80℃ are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4668 mL	7.3341 mL	14.6682 mL	73.3410 mL
5 mM	0.2934 mL	1.4668 mL	2.9336 mL	14.6682 mL
10 mM	0.1467 mL	0.7334 mL	1.4668 mL	7.3341 mL
20 mM	0.0733 mL	0.3667 mL	0.7334 mL	3.6670 mL
50 mM	0.0293 mL	0.1467 mL	0.2934 mL	1.4668 mL
100 mM	0.0147 mL	0.0733 mL	0.1467 mL	0.7334 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Fmoc-Ala-Glu-Asn-Lys-NH-2Fmoc Ala Glu Asn Lys NH2FmocAlaGluAsnLysNH2