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Foliglurax monohydrochloride

Name: Foliglurax monohydrochloride
Brand: TargetMol
SKU: T11311
Price: 55 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T11311Cas No. 2133294-96-7

Alias PXT002331 (monohydrochloride)

Foliglurax monohydrochloride Antiparkinsonian effect. is a highly selective and potent, brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) , with an EC50 of 79 nM.

Foliglurax monohydrochloride

😃Good

Catalog No. T11311Alias PXT002331 (monohydrochloride)Cas No. 2133294-96-7

Pack Size	Price	Availability
5 mg	$427	6-8 weeks
25 mg	$1,330	6-8 weeks
50 mg	$1,740	6-8 weeks
100 mg	$2,500	6-8 weeks

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Product Introduction

Bioactivity

Description	Foliglurax monohydrochloride Antiparkinsonian effect. is a highly selective and potent, brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) , with an EC50 of 79 nM.
Targets&IC50	mGlu4:79 nM （EC50）
In vitro	Foliglurax, might revolutionize the field of mGlu4 receptor drug targeting in CNS disorders.a highly selective and potent mGlu4 receptor PAM with a marked brain-penetrance feature.
Alias	PXT002331 (monohydrochloride)

Chemical Properties

Molecular Weight	457.97
Formula	C₂₃H₂₄ClN₃O₃S
Cas No.	2133294-96-7
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 5 mg/mL (10.92 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1835 mL	10.9177 mL	21.8355 mL	109.1775 mL
5 mM	0.4367 mL	2.1835 mL	4.3671 mL	21.8355 mL
10 mM	0.2184 mL	1.0918 mL	2.1835 mL	10.9177 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

FoligluraxFoliglurax monohydrochloridePXT002331PXT-002331Foliglurax MonohydrochloridePXT 002331