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FTase-IN-1
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Catalog No. T61682Cas No. 2490538-41-3
FTase-IN-1 (compound 17a) is a highly effective farnesyl transferase (FTase) inhibitor with an IC50 value of 0.35 μM, demonstrating significant cytotoxicity and potent antitumor activity [1].
FTase-IN-1
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Catalog No. T61682Cas No. 2490538-41-3
FTase-IN-1 (compound 17a) is a highly effective farnesyl transferase (FTase) inhibitor with an IC50 value of 0.35 μM, demonstrating significant cytotoxicity and potent antitumor activity [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | 6-8 weeks | |
| 50 mg | $1,980 | 6-8 weeks | |
| 100 mg | $2,500 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | FTase-IN-1 (compound 17a) is a highly effective farnesyl transferase (FTase) inhibitor with an IC50 value of 0.35 μM, demonstrating significant cytotoxicity and potent antitumor activity [1]. |
| In vitro | FTase-IN-1 (compound 17a) at 10 μM over 48 hours inhibits farnesyl transferase (FTase) and significantly suppresses NCI-60 cell proliferation in vitro [1]. It halts various cancer cell lines' growth, achieving GI50 values of 1.8 to 6.5 nM [1]. Cell Viability Assays [1] show marked inhibition of cancer cell growth, including lung (NCI-H522), colon (COLO-205 and HT29), glioblastoma (SF-539), melanoma (MDA-MB-435), ovarian (OVCAR-3), and renal (A498) cancers. |
| Molecular Weight | 384.45 |
| Formula | C23H16N2O2S |
| Cas No. | 2490538-41-3 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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