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FXR agonist 3

Name: FXR agonist 3
Brand: TargetMol
SKU: T74996
Price: 120 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T74996

FXR agonist 3 is an anti-NASH compound with antifibrotic and anti-fibrotic activity, inhibiting the expression of COL1A1, TGF-β1, α-SMA, and TIMP1, with an IC50 value of 8.19 μmol/L for COL1A1. FXR agonist 3 ameliorates CDAHFD and BDL-induced liver injury in vivo by activating FXR.

FXR agonist 3

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Purity: 95.04%

Catalog No. T74996

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1 mg	$120	In Stock

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Purity:95.04%

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COA HNMR HPLC

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Product Introduction

Bioactivity

Description	FXR agonist 3 is an anti-NASH compound with antifibrotic and anti-fibrotic activity, inhibiting the expression of COL1A1, TGF-β1, α-SMA, and TIMP1, with an IC50 value of 8.19 μmol/L for COL1A1. FXR agonist 3 ameliorates CDAHFD and BDL-induced liver injury in vivo by activating FXR.
In vitro	In LX-2 cells, FXR agonist 3 (0, 2.5, 5, 7.5, and 10 μM; 24 hours; with or without 2 ng/mL TGF-β1 for another 24 hours) decreased COL1A1, TGF-β1, α-SMA, and TIMP1 protein expressions in a dose-dependent manner[1].
In vivo	In C57BL/6 N mice fed a CDAHFD diet for 16 weeks, FXR agonist 3 (200 mg/kg; oral gavage; daily for 4 weeks after CDAHFD-induced) decreased the expression of IL-1β and IL-6 in the liver[1].

Chemical Properties

Molecular Weight	521.12
Formula	C₂₈H₂₈BrNO₄
Smiles	COC1=CC2=C(C=C1OC)CC[N+]3=C2C=C4C(C(OCC5=CC=CC(C)=C5)=C(OC)C=C4)=C3.[Br-]

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 200 mg/mL (382.83 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9189 mL	9.5947 mL	19.1894 mL	95.9472 mL
5 mM	0.3838 mL	1.9189 mL	3.8379 mL	19.1894 mL
10 mM	0.1919 mL	0.9595 mL	1.9189 mL	9.5947 mL
20 mM	0.0959 mL	0.4797 mL	0.9595 mL	4.7974 mL
50 mM	0.0384 mL	0.1919 mL	0.3838 mL	1.9189 mL
100 mM	0.0192 mL	0.0959 mL	0.1919 mL	0.9595 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc