Shopping Cart
- Remove All
![TargetMol](https://www.targetmol.com/storage/error/oops.webp)
Your shopping cart is currently empty
Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,520 | 6-8 weeks | |
50 mg | $1,980 | 6-8 weeks | |
100 mg | $2,500 | 6-8 weeks |
Description | GABAA receptor agent 7 (compound 5c) is a potent positive modulator of the GABAA receptor with anticonvulsant activity in vitro and in vivo, and low neurotoxicity, making it suitable for epilepsy research [1]. |
In vitro | GABAA receptor agent 7 (compound 5c) exhibits anticonvulsant properties, demonstrating an inhibitory concentration (IC50) of 0.452 μM in the 4-AP induced hyper-excitability model [1]. Additionally, it enhances GABA-induced activation of the GABAA1 receptor dose-dependently within a concentration range of 0.01-100 μM over a period of 0-140 seconds, with an effective concentration (EC50) of 3.08 μM [1]. |
In vivo | GABAA receptor agent 7 demonstrates anticonvulsant properties in mice, achieving an effective dose 50 (ED50) of 31.81 mg/kg and a toxic dose 50 (TD50) of 547.89 mg/kg [1]. This compound specifically mitigates seizures induced by pentylenetetrazol (PTZ) without affecting those caused by maximal electroshock (MES) in mice [1]. |
Molecular Weight | 336.77 |
Formula | C18H13ClN4O |
Cas No. | 2376841-18-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.