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GDC-0310

Name: GDC-0310
Brand: TargetMol
SKU: T39208
Price: 29 USD
Availability: InStock
Rating: 4.5 (1 reviews)

GDC-0310 is a selective acyl-sulfonamide inhibitor targeting the Na_v1.7 channel, with a potent inhibitory concentration (IC_50) of 0.6 nM against hNa_v1.7.

Catalog No. T39208Cas No. 1788063-52-4

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GDC-0310

Catalog No. T39208Cas No. 1788063-52-4

GDC-0310 is a selective acyl-sulfonamide inhibitor targeting the Na_v1.7 channel, with a potent inhibitory concentration (IC_50) of 0.6 nM against hNa_v1.7.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$165	8-10 weeks
5 mg	$413	8-10 weeks
10 mg	$655	8-10 weeks
25 mg	$987	8-10 weeks
50 mg	$1,390	8-10 weeks
100 mg	$1,880	8-10 weeks

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Product Introduction

Bioactivity

Description	GDC-0310 is a selective acyl-sulfonamide inhibitor targeting the Na_v1.7 channel, with a potent inhibitory concentration (IC_50) of 0.6 nM against hNa_v1.7.
Targets&IC50	Nav1.5 (human):551 nM (IC50), Nav1.2 (human):38 nM (IC50), Nav1.4 (human):3.4 nM (IC50), Nav1.1 (human):202 nM (IC50), Nav1.6 (human):198 nM (IC50)
In vitro	GDC-0310 demonstrates an in vivo EC50 of 1.1 μM and a Ki of 1.8 nM for Nav1.7[1].
In vivo	GDC-0310 demonstrates significantly enhanced selectivity for Na v channels and favorable ADME (Absorption, Distribution, Metabolism, and Excretion) characteristics. The compound exhibits half-lives (t1/2) of 5 hours in rats (at a dose of 5 mg/kg, intravenously), 46 hours in dogs (1 mg/kg, intravenously), and 4.4 hours in cynomolgus monkeys (2 mg/kg, intravenously).

Chemical Properties

Molecular Weight	543.48
Formula	C₂₅H₂₉Cl₂FN₂O₄S
Cas No.	1788063-52-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

GDC0310GDC-0310GDC 0310