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Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $108 | 5 days | |
50 mg | $747 | 6-8 weeks | |
100 mg | $1,190 | 6-8 weeks |
Description | GGsTop is a non-toxic and irreversible inhibitor of γ glutamyl transpeptidase (GGT) (Ki: 170 μM for Human GGT). GGsTop protects hepatic ischemia-reperfusion injury in the rat model. GGsTop shows Kons of 150±10 and 51±3 /(M·s) against E.coli GGT and human GGT, respectively. |
In vitro | GGsTop is a non-toxic compound, completely inhibits WT human GGT in 1 min at 1 mM, but less potent against the K562S mutant [2]. |
In vivo | GGsTop also decreases 4-HNE and TNF-α production and decreases hepatic necrosis in rats. GGsTop (1 mg/kg) lowers levels of ALT, AST, γ-GT at 12, 24, and 48 h after ischemia-reperfusion in rats [3]. |
Alias | Nahlsgen |
Molecular Weight | 331.26 |
Formula | C13H18NO7P |
Cas No. | 926281-37-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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