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GGsTop
🥰Excellent
Catalog No. T15379Cas No. 926281-37-0
Alias Nahlsgen
GGsTop (Nahlsgen) is a highly selective and irreversible inhibitor of γ-glutamyltransferase (GGT) with antiaging activity.
GGsTop
🥰Excellent
Purity: 98.96%
Catalog No. T15379Alias NahlsgenCas No. 926281-37-0
GGsTop (Nahlsgen) is a highly selective and irreversible inhibitor of γ-glutamyltransferase (GGT) with antiaging activity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $99 | In Stock | |
| 5 mg | Inquiry | In Stock |
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Purity:98.96%
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.Product Introduction
Bioactivity
Chemical Properties
| Description | GGsTop (Nahlsgen) is a highly selective and irreversible inhibitor of γ-glutamyltransferase (GGT) with antiaging activity. |
| Targets&IC50 | GGT (human):（ki）170 μM |
| In vitro | GGsTop is a potent, highly selective, and irreversible inhibitor of γ-glutamyl transpeptidase (GGT), exhibiting a Ki value of 170 μM against human GGT[1]. |
| In vivo | In 9-week-old male rats, GGsTop (1 mg/kg; administered via the inferior vena cava for 12, 24, and 48 hours continuously) was able to reduce serum levels of ALT and AST, and prevented the elevation of serum γ-GT levels in the IR-GGsTop group [3]. |
| Alias | Nahlsgen |
| Molecular Weight | 331.26 |
| Formula | C13H18NO7P |
| Cas No. | 926281-37-0 |
| Smiles | O=C(O)CC=1C=CC=C(OP(=O)(OC)CCC(N)C(=O)O)C1 |
| Relative Density. | 1.403 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (241.50 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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