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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,520 | 6-8 weeks | |
50 mg | $1,980 | 6-8 weeks | |
100 mg | $2,500 | 6-8 weeks |
Description | GGTI-2154 is a potent, selective geranylgeranyltransferase I (GGTase I) inhibitor, boasting an IC50 of 21 nM and demonstrating over 200-fold selectivity against FTase (IC50=5600 nM). Its efficacy and specificity make it a valuable tool for cancer research[1][2]. |
In vitro | GGTI-2154 inhibits the transfer of geranylgeranyl from [3H]GGPP to H-Ras CVLL with an IC50 of 21 nM[1]. |
In vivo | GGTI-2154 (100 mg/kg/day; s.c. for 14 days) induces breast tumor regression in MMTV-Ν-Ha-Ras transgenic mice[2], and at a dosage of 50 mg/kg/day (i.p. for 50 days), it inhibits A-549 tumor growth in nude mice by 60%[1]. |
Molecular Weight | 420.5 |
Formula | C24H28N4O3 |
Cas No. | 251577-10-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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