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Gly-Arg-AMC (hydrochloride)

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Catalog No. T35932Cas No. 70274-78-1

Gly-Arg-AMC is a fluorogenic substrate for cathepsin C.1 Upon enzymatic cleavage by cathepsin C, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify cathepsin C activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively.

Gly-Arg-AMC (hydrochloride)

Gly-Arg-AMC (hydrochloride)

😃Good
Catalog No. T35932Cas No. 70274-78-1
Gly-Arg-AMC is a fluorogenic substrate for cathepsin C.1 Upon enzymatic cleavage by cathepsin C, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify cathepsin C activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively.
Pack SizePriceAvailabilityQuantity
1 mgInquiry35 days
5 mgInquiry35 days
10 mgInquiry35 days
25 mgInquiry35 days
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Product Introduction

Bioactivity
Description
Gly-Arg-AMC is a fluorogenic substrate for cathepsin C.1 Upon enzymatic cleavage by cathepsin C, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify cathepsin C activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively.
|1. Rubach, J.K., Cui, G., Schneck, J.L., et al. The amino-acid substituents of dipeptide substrates of cathepsin C can determine the rate-limiting steps of catalysis. Biochemistry 51(38), 7551-7568 (2012).
Chemical Properties
Molecular Weight424.89
FormulaC18H25ClN6O4
Cas No.70274-78-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO:PBS (pH 7.2) (1:1): 0.5 mg/mL (1.18 mM), Sonication is recommended.
DMSO: 30 mg/mL (70.61 mM), Sonication is recommended.
Ethanol: 20 mg/mL (47.07 mM), Sonication is recommended.
DMF: 30 mg/mL (70.61 mM), Sonication is recommended.
Solution Preparation Table
Ethanol/DMSO/DMF
1mg5mg10mg50mg
5 mM0.4707 mL2.3536 mL4.7071 mL23.5355 mL
10 mM0.2354 mL1.1768 mL2.3536 mL11.7678 mL
20 mM0.1177 mL0.5884 mL1.1768 mL5.8839 mL
DMSO/DMF
1mg5mg10mg50mg
50 mM0.0471 mL0.2354 mL0.4707 mL2.3536 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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Keywords

Gly-Arg-AMCGly Arg AMC (hydrochloride)GlyArgAMC (hydrochloride)
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