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Glycolate oxidase-IN-1
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Catalog No. T82289Cas No. 330977-65-6
Glycolate oxidase-IN-1 (compound 26), a salicylic acid derivative, serves as an inhibitor of glycolate oxidase (GO) and exhibits an inhibitory concentration (IC50) of 38.2 μM. It is efficacious in reducing oxalate production in hyperoxaluric hepatocytes and has potential applications in researching primary hyperoxaluria type 1 (PH1) [1].
Glycolate oxidase-IN-1
😃Good
Catalog No. T82289Cas No. 330977-65-6
Glycolate oxidase-IN-1 (compound 26), a salicylic acid derivative, serves as an inhibitor of glycolate oxidase (GO) and exhibits an inhibitory concentration (IC50) of 38.2 μM. It is efficacious in reducing oxalate production in hyperoxaluric hepatocytes and has potential applications in researching primary hyperoxaluria type 1 (PH1) [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | Inquiry | 8-10 weeks | |
| 50 mg | Inquiry | 8-10 weeks |
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Chemical Properties
| Description | Glycolate oxidase-IN-1 (compound 26), a salicylic acid derivative, serves as an inhibitor of glycolate oxidase (GO) and exhibits an inhibitory concentration (IC50) of 38.2 μM. It is efficacious in reducing oxalate production in hyperoxaluric hepatocytes and has potential applications in researching primary hyperoxaluria type 1 (PH1) [1]. |
| In vitro | When treated with Glycolate oxidase-IN-1 (compound 26) (0-12.5 μM, 48 h), murine hepatocytes exhibited a significant reduction in excreted oxalate levels, with a 67.3 ± 32% decrease observed at a concentration of 6.25 μM. |
| Molecular Weight | 232.19 |
| Formula | C12H8O5 |
| Cas No. | 330977-65-6 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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