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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,970 | 8-10 weeks | |
50 mg | $2,580 | 8-10 weeks | |
100 mg | $3,400 | 8-10 weeks |
Description | GNE-220 is a potent and selective inhibitor of MAP4K4 (IC50: 7 nM). |
In vitro | GNE-220 alters human umbilical vein endothelial cells (HUVEC) sprout morphology.?GNE-220 also reduces pERM+ retraction fibres in a dose-dependent manner.?GNE-220 also dose-dependently increased the number of active-INTβ1+ long focal adhesions (FAs).GNE-220 also inhibits a few other kinases with IC50s of 9 nM, 476 nM and 1.1 μM for MINK (MAP4K6), DMPK and KHS1 (MAP4K5), respectively. |
Molecular Weight | 438.53 |
Formula | C25H26N8 |
Cas No. | 1199590-75-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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