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GPR40 agonist 6

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Catalog No. T61055Cas No. 1798751-25-3

GPR40 agonist 6 (Compound 7a) is a potent and selective agonist of free fatty acid receptor 1 (FFAR1 or GPR40) with an EC50 of 0.058 μM against GPR40 [1].

GPR40 agonist 6

GPR40 agonist 6

😃Good
Catalog No. T61055Cas No. 1798751-25-3
GPR40 agonist 6 (Compound 7a) is a potent and selective agonist of free fatty acid receptor 1 (FFAR1 or GPR40) with an EC50 of 0.058 μM against GPR40 [1].
Pack SizePriceAvailabilityQuantity
2 mg$535 days
1 mL x 10 mM (in DMSO)$1307-10 days
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Product Introduction

Bioactivity
Description
GPR40 agonist 6 (Compound 7a) is a potent and selective agonist of free fatty acid receptor 1 (FFAR1 or GPR40) with an EC50 of 0.058 μM against GPR40 [1].
In vitro
GPR40 agonist 6 (Compound 7a) exhibits an excellent ADME profile with negligible inhibition of key cytochrome P450 isoforms (1A2, 2C9, 2C19, 2D6, and 3A4) at 5 μM. It shows 98.6% human plasma protein binding, 404 μM aqueous solubility in PBS (pH 7.4), a microsomal stability half-life of 434 minutes in mice, and a Caco-2 permeability rate of 15.2 x 10^-6 cm/s, indicating promising pharmacokinetic properties.
Chemical Properties
Molecular Weight337.37
FormulaC20H19NO4
Cas No.1798751-25-3
Storage & Solubility Information
StorageShipping with blue ice.

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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