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GSK-J2

Name: GSK-J2
Brand: TargetMol
SKU: T11476
Price: 46 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11476Cas No. 1394854-52-4

GSK-J2 is an inactive enantiomer of GSK-J1 that is lipophilic and serves as an inactive control for GSK-J21.

GSK-J2

🥰Excellent

Catalog No. T11476Cas No. 1394854-52-4

GSK-J2 is an inactive enantiomer of GSK-J1 that is lipophilic and serves as an inactive control for GSK-J21.

Pack Size	Price	Availability
2 mg	$46	In Stock
5 mg	$72	In Stock
10 mg	$98	In Stock
25 mg	$168	In Stock
50 mg	$247	In Stock
100 mg	$365	In Stock
200 mg	$542	In Stock
1 mL x 10 mM (in DMSO)	$108	In Stock

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COA HNMR

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Product Introduction

Bioactivity

Description	GSK-J2 is an inactive enantiomer of GSK-J1 that is lipophilic and serves as an inactive control for GSK-J21.
Targets&IC50	UTX (KDM6A):100 μM, KDM6B:49 μM
In vitro	GSK-J2, an isomer of GSK-J1, does not have any specific activity and is less active against KDM6A and KDM6B, with IC50s greater than 100 μM and 49 μM, respectively. [1]

Chemical Properties

Molecular Weight	389.45
Formula	C₂₂H₂₃N₅O₂
Cas No.	1394854-52-4
Smiles	O=C(O)CCNC=1N=C(N=C(C1)N2CCC=3C=CC=CC3CC2)C4=CN=CC=C4
Relative Density.	1.292 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 30 mg/mL (77.03 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5677 mL	12.8386 mL	25.6772 mL	128.3862 mL
5 mM	0.5135 mL	2.5677 mL	5.1354 mL	25.6772 mL
10 mM	0.2568 mL	1.2839 mL	2.5677 mL	12.8386 mL
20 mM	0.1284 mL	0.6419 mL	1.2839 mL	6.4193 mL
50 mM	0.0514 mL	0.2568 mL	0.5135 mL	2.5677 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

GSK-J-2GSK-J2GSK J2