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Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $95 | 5 days |
Description | GSK682753A is a selective and highly potent inverse agonist of the epstein-barr virus-induced receptor 2 (EBI2; IC50: 53.6 nM). |
In vitro | GSK682753A exhibits dose-dependent inhibition of EBI2, achieving an IC50 of 53.6 nM. It demonstrates similar potency in inhibiting ERK phosphorylation, GTPγS binding, and activation of the cAMP-response element-binding protein (CREB). Additionally, GSK682753A acts as a selective and highly potent inverse agonist for both murine and human EBI2, effectively blocking G protein-dependent and potentially G protein-independent signals. In assays using cAMP-response element-binding protein-based reporters and guanosine 5'-3-O-(thio)-triphosphate (GTPγS) binding, GSK682753A shows a potency range of 2.6-53.6 nM and achieves an inhibitory efficacy of 75%. |
Molecular Weight | 479.78 |
Formula | C23H21Cl3N2O3 |
Cas No. | 1334294-76-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 27 mg/mL (56.28 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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