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Guanfu base I

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Catalog No. T11510Cas No. 110225-59-7
Alias Acorine

Guanfu base I is an active metabolite of Guanfu base A, isolated from Aconitum coreanum. It have a potent anti-arrhythmic effect.

Guanfu base I

Guanfu base I

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Catalog No. T11510Alias AcorineCas No. 110225-59-7
Guanfu base I is an active metabolite of Guanfu base A, isolated from Aconitum coreanum. It have a potent anti-arrhythmic effect.
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Product Introduction

Bioactivity
Description
Guanfu base I is an active metabolite of Guanfu base A, isolated from Aconitum coreanum. It have a potent anti-arrhythmic effect.
In vivo
The pharmacokinetics of Guanfu base I in Sprague-Dawley rats were examined, showing linearity in the 0.05-20 μg/mL concentration range with recovery exceeding 80%. Intraday and interday precision, as relative standard deviation, were generally good. Following intravenous injection, plasma Guanfu base I concentration declined bi-phasically with a terminal elimination half-life of 2.49 hours and a total plasma clearance of 1.46 L/h/kg. After oral dosing, the plasma concentration peaked within 0.5 hours, and the absolute bioavailability was 71.31%.
AliasAcorine
Chemical Properties
Molecular Weight387.476
FormulaC22H29NO5
Cas No.110225-59-7
Relative Density.1.48 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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