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Guanfu base I is an active metabolite of Guanfu base A, isolated from Aconitum coreanum. It have a potent anti-arrhythmic effect.
Pack Size | Price | Availability | Quantity |
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100 mg | Inquiry | Backorder | |
500 mg | Inquiry | Backorder |
Description | Guanfu base I is an active metabolite of Guanfu base A, isolated from Aconitum coreanum. It have a potent anti-arrhythmic effect. |
In vivo | The pharmacokinetics of Guanfu base I in Sprague-Dawley rats were examined, showing linearity in the 0.05-20 μg/mL concentration range with recovery exceeding 80%. Intraday and interday precision, as relative standard deviation, were generally good. Following intravenous injection, plasma Guanfu base I concentration declined bi-phasically with a terminal elimination half-life of 2.49 hours and a total plasma clearance of 1.46 L/h/kg. After oral dosing, the plasma concentration peaked within 0.5 hours, and the absolute bioavailability was 71.31%. |
Alias | Acorine |
Molecular Weight | 387.476 |
Formula | C22H29NO5 |
Cas No. | 110225-59-7 |
Relative Density. | 1.48 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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