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HA-100 hydrochloride

Catalog No. T38842Cas No. 141543-63-7

HA-100 hydrochloride is a powerful protein kinase inhibitor, exhibiting IC50 values of 4 μM, 8 μM, 12 μM, and 240 μM for cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC), and MLC-kinase, respectively. Additionally, HA-100 hydrochloride is utilized as a ROCK inhibitor.

HA-100 hydrochloride
Other Forms of HA-100 hydrochloride:
HA-100T764884468-24-6
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HA-100 hydrochloride

Catalog No. T38842Cas No. 141543-63-7
HA-100 hydrochloride is a powerful protein kinase inhibitor, exhibiting IC50 values of 4 μM, 8 μM, 12 μM, and 240 μM for cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC), and MLC-kinase, respectively. Additionally, HA-100 hydrochloride is utilized as a ROCK inhibitor.
Pack SizePriceAvailabilityQuantity
25 mg$1,5201-2 weeks
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Product Introduction

Bioactivity
Description
HA-100 hydrochloride is a powerful protein kinase inhibitor, exhibiting IC50 values of 4 μM, 8 μM, 12 μM, and 240 μM for cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC), and MLC-kinase, respectively. Additionally, HA-100 hydrochloride is utilized as a ROCK inhibitor.
Targets&IC50
PKG:4 μM (IC50), PKA:8 μM (IC50), PKC:12 μM (IC50), MLCK:240 μM (IC50)
In vitro
HA-100 hydrochloride acts as a competitive inhibitor for both MLC-kinase and PKC in the presence of ATP, exhibiting inhibition constants (Kis) of 61 μM for MLC-kinase and 6.5 μM for PKC, respectively[1].
Chemical Properties
Molecular Weight313.8
FormulaC13H16ClN3O2S
Cas No.141543-63-7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

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