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HB007
Catalog No. T37646Cas No. 2387821-46-5
HB007 is a potent degrader of small ubiquitin-related modifier 1 (SUMO1). It mediates the ubiquitination and subsequent degradation of SUMO1, leading to a decrease in tumor growth in vivo. HB007 is a valuable tool for investigating brain, breast, colon, and lung cancers[1][2].
HB007
Catalog No. T37646Cas No. 2387821-46-5
HB007 is a potent degrader of small ubiquitin-related modifier 1 (SUMO1). It mediates the ubiquitination and subsequent degradation of SUMO1, leading to a decrease in tumor growth in vivo. HB007 is a valuable tool for investigating brain, breast, colon, and lung cancers[1][2].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $854 | 6-8 weeks | |
| 50 mg | $1,110 | 6-8 weeks | |
| 100 mg | $1,610 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | HB007 is a potent degrader of small ubiquitin-related modifier 1 (SUMO1). It mediates the ubiquitination and subsequent degradation of SUMO1, leading to a decrease in tumor growth in vivo. HB007 is a valuable tool for investigating brain, breast, colon, and lung cancers[1][2]. |
| In vitro | HB007 (compound 24), at concentrations ranging from 0.1 to 100 μM, effectively inhibits the growth of LN229 cells in a dose-dependent manner [t1]. Additionally, at concentrations between 10 and 25 μM, HB007 selectively decreases both the conjugation and overall protein levels of SUMO1, without affecting the levels of SUMO2/3 or ubiquitin (UB) in LN229 cells [t1]. |
| In vivo | HB007 (compound 24) (25-50 mg/kg; intraperitoneally administered for 15 days) significantly inhibited colon and lung tumor growth without impacting the body weight of mice[1]. |
| Molecular Weight | 328.78 |
| Formula | C15H9ClN4OS |
| Cas No. | 2387821-46-5 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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