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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $2,870 | 10-14 weeks | |
50 mg | $3,780 | 10-14 weeks | |
100 mg | $5,200 | 10-14 weeks |
Description | HCV-IN-7 is an orally active and potent pan-genotypic HCV NS5A inhibitor (IC50s: 3-47 pM) with a superior pan-genotypic profile, good pharmacokinetic properties, and favorable liver uptake. |
Targets&IC50 | HCV NS5A:3-47 pM |
In vitro | HCV-IN-7 (10 μM) has cytotoxicity of 14%, 22%, 36% in Huh7, HepG2 and HEK cells, respectively. ?HCV-IN-7 has a less complex central tricyclic core as novel and potent pan-genotypic NS5A inhibitors with good pharmacokinetic profile.?HCV-IN-7 inhibits GT1b (IC50=12 pM), GT2a (IC50=5 pM), GT1a (IC50=27 pM), GT3a (IC50=47 pM), GT4a (IC50=3 pM), GT6a (IC50=28 pM). ?HCV-IN-7 (10 μM) has 12%, 42%, 12% inhibition for CYP2D6, CYP2C9, CYP3A4, respectively. |
In vivo | HCV-IN-7 (iv; 1 mg/kg) exhibits a T1/2 of 4 hours, CL of 6 mL/min/kg, and Vss of 2 L/kg in dogs, while (po; 10 mg/kg) it has a Cmax of 5 μM and AUClast of 49 μM. In rats, HCV-IN-7 (iv; 1 mg/kg) shows a T1/2 of 2 hours, CL of 11 mL/min/kg, and Vss of 2 L/kg, with (po; 10 mg/kg) a Cmax of 1 μM and AUClast of 6 μM. |
Molecular Weight | 768.92 |
Formula | C40H48N8O6S |
Cas No. | 1449756-86-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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