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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,520 | 6-8 weeks | |
50 mg | $1,980 | 6-8 weeks | |
100 mg | $2,500 | 6-8 weeks |
Description | HDAC6-IN-6 (compound 6a) is a potent inhibitor of HDAC6 that can penetrate BBB with an IC50 value of 0.025 μM. HDAC6-IN-6 has potent inhibitory activity against AChE and Aβ 1-42 self-aggregation with IC50 values of 0.72 and 3.0 μM. HDAC6-IN-6 can enhance the outgrowth of neurite without significant neurotoxicity [1]. |
In vitro | HDAC6-IN-6 (compound 6a) effectively promotes acetylation of histone H3 and α-tubulin in a dose-dependent fashion, demonstrating half-maximal effective concentrations (EC 50) of 7.96 μM and 8 μM, respectively [1]. |
Molecular Weight | 329.35 |
Formula | C20H15N3O2 |
Cas No. | 2413603-10-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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