Shopping Cart
- Remove All
- Your shopping cart is currently empty
Hedgehog (Hh) proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of Smoothened. In vertebrates, this ultimately leads to the activation of the zinc-finger transcription factors of the Gli family. Overactivation of this pathway contributes to certain cancers, including glioblastoma, for which the Gli proteins are named. Hh antagonist VIII is a cell-permeable quinazolinyl-urea compound that has been shown to inhibit Gli transcription activity with an IC50 value of 70 nM.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
500 μg | 173 € | 35 days | |
1 mg | 281 € | 35 days | |
5 mg | 515 € | 35 days |
Description | Hedgehog (Hh) proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of Smoothened. In vertebrates, this ultimately leads to the activation of the zinc-finger transcription factors of the Gli family. Overactivation of this pathway contributes to certain cancers, including glioblastoma, for which the Gli proteins are named. Hh antagonist VIII is a cell-permeable quinazolinyl-urea compound that has been shown to inhibit Gli transcription activity with an IC50 value of 70 nM. |
Molecular Weight | 490.84 |
Formula | C23H15ClF4N4O2 |
Cas No. | 330796-24-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | Ethanol: 10 mg/mL DMF: 30 mg/mL DMF:PBS(pH7.2) (1:2): 0.3 mg/mL DMSO: 25 mg/mL |
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.