Helospectin I, a neuropeptide belonging to the vasoactive intestinal peptide (VIP) family, exhibits vasodilatory and antihypertensive properties, effectively reducing blood pressure. It was initially isolated from the salivary gland venom of the lizard Heloderma suspectum [1] [2].

Helospectin I, administered intravenously at doses ranging from 0.03 to 2 nmol/kg, lowers blood pressure in rats when infused at a volume of 100 μL into the left jugular vein [2]. At a dosage of 0.1 to 0.8 nmol/kg, this compound also elevates plasma glucagon concentrations in mice [3].