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Heparin Lithium

🥰Excellent
Catalog No. T64262Cas No. 9045-22-1

Heparin Lithium salt is an anticoagulant that reversibly binds to antithrombin III (ATIII) and enhances its inhibitory effect on coagulation factors, such as thrombin and factor Xa, significantly enhancing anticoagulant activity.

Heparin Lithium

Heparin Lithium

🥰Excellent
Catalog No. T64262Cas No. 9045-22-1
Heparin Lithium salt is an anticoagulant that reversibly binds to antithrombin III (ATIII) and enhances its inhibitory effect on coagulation factors, such as thrombin and factor Xa, significantly enhancing anticoagulant activity.
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100 mg$52 In Stock
500 mg$73 In Stock
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Product Introduction

Bioactivity
Description
Heparin Lithium salt is an anticoagulant that reversibly binds to antithrombin III (ATIII) and enhances its inhibitory effect on coagulation factors, such as thrombin and factor Xa, significantly enhancing anticoagulant activity.
In vitro
Heparin Lithium is an effective anticoagulant because it accelerates the rate at which antithrombin inhibits serine proteases in the coagulation cascade.
Heparin Lithium can bind to AT III and thrombin in the ternary complex, increasing the bimolecular rate constant that inhibits thrombin by 2000 times.
Heparin Lithium is thought to function as an anticoagulant primarily through its interaction with AT III by enhancing AT-III-mediated inhibition of clotting factors, including thrombin and factor Xa.
Heparin Lithium is mainly located in tissue mast cell granules closely related to immune response.
Heparin Lithium is subjected to multiple contacts with FGF-2 and FGFR-1 to stabilize FGF-FGFR binding. Heparin Lithium is also in contact with FGFR-1 of adjacent FGF-FGFR complexes, thus appearing to promote FGFR dimerization. [1]
Chemical Properties
FormulaC14H25NO20S3
Cas No.9045-22-1
Storage & Solubility Information
Storagekeep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: < 1 mg/ml (slightly soluble or insoluble)
H2O: 80 mg/mL, Sonication is recommended.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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