HER2-IN-10, a psoralen derivative, induces apoptosis and demonstrates anti-breast cancer activity and light-activated cytotoxicity [1].

HER2-IN-10 (50 μM) exhibits phototoxicity against SK-BR-3 cells with an IC 50 of 3.05 μM [1]. At concentrations ranging from 1-50 μM for 48 hours, under UVA irradiation, it alters cell morphology and increases the apoptotic index [1]. Apoptosis analysis indicated cell breakdown into apoptotic bodies at higher concentrations (10, 20, and 50 μM) and cell shrinkage with plasma membrane blebbing at lower concentrations (1, 2.5, and 5 μM) [1].