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HER2-IN-14

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Catalog No. T75165Cas No. 2414056-35-0

HER2-IN-14 (Compound 34) is a potent HER2 inhibitor with an IC50 of 18 nM and demonstrates inhibitory activity against wild-type EGFR (wt-EGFR) with an IC50 of 6.3 μM [1].

HER2-IN-14

HER2-IN-14

😃Good
Catalog No. T75165Cas No. 2414056-35-0
HER2-IN-14 (Compound 34) is a potent HER2 inhibitor with an IC50 of 18 nM and demonstrates inhibitory activity against wild-type EGFR (wt-EGFR) with an IC50 of 6.3 μM [1].
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Product Introduction

Bioactivity
Description
HER2-IN-14 (Compound 34) is a potent HER2 inhibitor with an IC50 of 18 nM and demonstrates inhibitory activity against wild-type EGFR (wt-EGFR) with an IC50 of 6.3 μM [1].
Chemical Properties
Molecular Weight568.96
FormulaC26H23ClF2N8O3
Cas No.2414056-35-0
Storage & Solubility Information
StorageShipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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