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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,520 | 10-14 weeks | |
50 mg | $1,980 | 10-14 weeks | |
100 mg | $2,500 | 10-14 weeks |
Description | HIF-1α-IN-5 is an inhibitor of HIF-1α with an IC 50 value of 24 nM in HEK293T cells that also inhibits the activity of MAO-A. HIF-1α-IN-5 downregulates the mRNA expressions of VEGF and PDK1 under hypoxia. HIF-1α-IN-5 has the potential to be used in the cancer research[1]. |
In vitro | HIF-1α-IN-5 (compound 15, 24 h) demonstrates inhibitory effects on HIF-1α transcription within HEK293T cells, exhibiting an IC50 value of 24 nM. In the same cell line and time frame, it dose-dependently decreases VEGF and PDK1 mRNA levels under hypoxic conditions, as verified by RT-PCR. Additionally, at a concentration of 10 μM, HIF-1α-IN-5 significantly reduces MAO-A and ADORA2A activities by 80.64% and 43.95%, respectively. |
Molecular Weight | 281.31 |
Formula | C16H15N3O2 |
Cas No. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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