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HIV-1 inhibitor-47

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Catalog No. T60342Cas No. 137448-39-6

HIV-1 inhibitor-47 is a compound that effectively inhibits HIV-1 by preventing the vif-dependent degradation of human APOBEC3G. It has a notable inhibition effect, with an IC50 value of 14.33 μM. Additionally, HIV-1 inhibitor-47 is involved in the synthesis of derivatives of 1-(2-pyrimidinyl)piperazine, which have the potential to exhibit antianxiety, antidepressant, and antipsychotic effects [1] [2] [3].

HIV-1 inhibitor-47

HIV-1 inhibitor-47

😃Good
Catalog No. T60342Cas No. 137448-39-6
HIV-1 inhibitor-47 is a compound that effectively inhibits HIV-1 by preventing the vif-dependent degradation of human APOBEC3G. It has a notable inhibition effect, with an IC50 value of 14.33 μM. Additionally, HIV-1 inhibitor-47 is involved in the synthesis of derivatives of 1-(2-pyrimidinyl)piperazine, which have the potential to exhibit antianxiety, antidepressant, and antipsychotic effects [1] [2] [3].
Pack SizePriceAvailabilityQuantity
25 mg$1,5206-8 weeks
50 mg$1,9806-8 weeks
100 mg$2,5006-8 weeks
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Product Introduction

Bioactivity
Description
HIV-1 inhibitor-47 is a compound that effectively inhibits HIV-1 by preventing the vif-dependent degradation of human APOBEC3G. It has a notable inhibition effect, with an IC50 value of 14.33 μM. Additionally, HIV-1 inhibitor-47 is involved in the synthesis of derivatives of 1-(2-pyrimidinyl)piperazine, which have the potential to exhibit antianxiety, antidepressant, and antipsychotic effects [1] [2] [3].
In vitro
APOBEC3G (A3G), a host cytidine deaminase, inhibits HIV-1 replication through its antiviral activity. Nonetheless, HIV-1 circumvents this defense by exploiting the cellular ubiquitin/proteasome degradation pathway [1]. HIV-1 inhibitor-47 targets the APOBEC3G-apolipoprotein B mRNA editing enzyme catalytic subunit 3G (human), disrupting the HIV-1 Vif-APOBEC3G interaction [2].
Chemical Properties
Molecular Weight242.28
FormulaC12H14N6
Cas No.137448-39-6
Storage & Solubility Information
StorageShipping with blue ice.

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