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hMAO-B-IN-9

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Catalog No. T89331

hMAO-B-IN-9 (Compound 25c) acts as a non-competitive inhibitor of monoamine oxidase B (MAO-B), with an IC50 value of 1.58 µM (hMAO-B). Additionally, it functions as a chelator, forming complexes with iron ions which suppress ferroptosis induced by erastin. This compound exhibits antioxidant activity through the downregulation of reactive oxygen species (ROS) levels. It has also been shown to improve cognitive functions in mice without significant toxicity at a dose of 30 mg/kg. Computer predictions suggest that hMAO-B-IN-9 is permeable to the blood-brain barrier.

hMAO-B-IN-9

hMAO-B-IN-9

😃Good
Catalog No. T89331
hMAO-B-IN-9 (Compound 25c) acts as a non-competitive inhibitor of monoamine oxidase B (MAO-B), with an IC50 value of 1.58 µM (hMAO-B). Additionally, it functions as a chelator, forming complexes with iron ions which suppress ferroptosis induced by erastin. This compound exhibits antioxidant activity through the downregulation of reactive oxygen species (ROS) levels. It has also been shown to improve cognitive functions in mice without significant toxicity at a dose of 30 mg/kg. Computer predictions suggest that hMAO-B-IN-9 is permeable to the blood-brain barrier.
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Product Introduction

Bioactivity
Description
hMAO-B-IN-9 (Compound 25c) acts as a non-competitive inhibitor of monoamine oxidase B (MAO-B), with an IC50 value of 1.58 µM (hMAO-B). Additionally, it functions as a chelator, forming complexes with iron ions which suppress ferroptosis induced by erastin. This compound exhibits antioxidant activity through the downregulation of reactive oxygen species (ROS) levels. It has also been shown to improve cognitive functions in mice without significant toxicity at a dose of 30 mg/kg. Computer predictions suggest that hMAO-B-IN-9 is permeable to the blood-brain barrier.
Chemical Properties
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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