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HMGB1-IN-1
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Catalog No. T78056
HMGB1-IN-1 (compound 6) exhibits potent inhibition of NO production in RAW264.7 cells, with an IC50 of 15.9 ± 0.6 μM, and effectively disrupts the HMGB1/NF-κB/NLRP3 signaling pathway, demonstrating promising anti-inflammatory and anti-sepsis properties, particularly in the context of renal injury [1].
HMGB1-IN-1
HMGB1-IN-1
😃Good
Catalog No. T78056
HMGB1-IN-1 (compound 6) exhibits potent inhibition of NO production in RAW264.7 cells, with an IC50 of 15.9 ± 0.6 μM, and effectively disrupts the HMGB1/NF-κB/NLRP3 signaling pathway, demonstrating promising anti-inflammatory and anti-sepsis properties, particularly in the context of renal injury [1].
| Pack Size | Price | Availability | Quantity |
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| 5 mg | Inquiry | Backorder | |
| 50 mg | Inquiry | Backorder |
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Bioactivity
Chemical Properties
| Description | HMGB1-IN-1 (compound 6) exhibits potent inhibition of NO production in RAW264.7 cells, with an IC50 of 15.9 ± 0.6 μM, and effectively disrupts the HMGB1/NF-κB/NLRP3 signaling pathway, demonstrating promising anti-inflammatory and anti-sepsis properties, particularly in the context of renal injury [1]. |
| In vitro | HMGB1-IN-1 (compound 6) (0-30 μM, 0-48 h) reduces IL-1β and TNF-α levels in RAW264.7 and HK-2 cells and demonstrates dose-dependent downregulation of NLRP3, P-NF-κB p65, and HMGB1 in activated HK-2 cells [1]. |
| In vivo | HMGB1-IN-1 (compound 6), when administered intraperitoneally at doses ranging from 15 to 30 mg/kg, demonstrates potent anti-inflammatory activity [1]. |
| Molecular Weight | 1042.22 |
| Formula | C57H75N3O15 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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