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Pack Size | Price | Availability | Quantity |
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5 mg | Inquiry | Backorder | |
50 mg | Inquiry | Backorder |
Description | HMGB1-IN-2 (compound 15) is a selective inhibitor of the highly conserved nuclear protein HMGB1, demonstrating no inhibitory effect at an IC50 of 20.2 μM in RAW264.7 cells. At a concentration of 30 μM, HMGB1-IN-2 reduces IL-1β, TNF-α, and caspase-1 p20 levels, and inhibits NF-κB p65 phosphorylation, providing anti-apoptotic effects. In vivo, HMGB1-IN-2 at a dose of 15 mg/kg administered intraperitoneally alleviates kidney injury in a mouse model of septic acute kidney injury. Furthermore, it inhibits Huh7 and A549 cells with IC50 values of 77.0 μM and 82.0 μM, respectively [1]. |
In vivo | HMGB1-IN-2 (compound 15) is solubilized in a 10% polyoxyethylene castor oil aqueous solution [1]. |
Molecular Weight | 926.14 |
Formula | C53H71N3O11 |
Cas No. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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