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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | Inquiry | 6-8 weeks | |
50 mg | Inquiry | 6-8 weeks | |
100 mg | Inquiry | 6-8 weeks |
Description | Homocarbonyltopsentin is a small-molecule TSL2-binding compound, binds to pentaloop conformations of TSL2 and promotes a shift to triloop conformations that display enhanced SMN2 exon 7 (E7) splicing (EC50: 16 μM). |
In vitro | Homocarbonyltopsentin ?(40 μM; 24 hours) increased 1.5-fold SMN protein expression compared to GM03813C cells treated with DMSO.Homocarbonyltopsentin ?(10-40 μM; 24 hours) shows an up to 5.2-fold decrease in the expression of E7-excluding SMN2 isoforms, and up to three-fold increase in E7-including isoforms in GM03813C cells. |
Alias | PK4C9 |
Molecular Weight | 370.36 |
Formula | C21H14N4O3 |
Cas No. | 172286-77-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 125 mg/mL (337.51 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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