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Homocarbonyltopsentin

Name: Homocarbonyltopsentin
Brand: TargetMol
SKU: T13723
Price: 47 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T13723Cas No. 172286-77-0

Alias PK4C9

Homocarbonyltopsentin is a small-molecule TSL2-binding compound, binds to pentaloop conformations of TSL2 and promotes a shift to triloop conformations that display enhanced SMN2 exon 7 (E7) splicing (EC50: 16 μM).

Homocarbonyltopsentin

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Catalog No. T13723Alias PK4C9Cas No. 172286-77-0

Pack Size	Price	Availability
25 mg	Inquiry	6-8 weeks
50 mg	Inquiry	6-8 weeks
100 mg	Inquiry	6-8 weeks

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Product Introduction

Bioactivity

Description	Homocarbonyltopsentin is a small-molecule TSL2-binding compound, binds to pentaloop conformations of TSL2 and promotes a shift to triloop conformations that display enhanced SMN2 exon 7 (E7) splicing (EC50: 16 μM).
In vitro	Homocarbonyltopsentin ?(40 μM; 24 hours) increased 1.5-fold SMN protein expression compared to GM03813C cells treated with DMSO.Homocarbonyltopsentin ?(10-40 μM; 24 hours) shows an up to 5.2-fold decrease in the expression of E7-excluding SMN2 isoforms, and up to three-fold increase in E7-including isoforms in GM03813C cells.
Alias	PK4C9

Chemical Properties

Molecular Weight	370.36
Formula	C₂₁H₁₄N₄O₃
Cas No.	172286-77-0
Relative Density.	1.539 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 125 mg/mL (337.51 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7001 mL	13.5004 mL	27.0008 mL	135.0038 mL
5 mM	0.5400 mL	2.7001 mL	5.4002 mL	27.0008 mL
10 mM	0.2700 mL	1.3500 mL	2.7001 mL	13.5004 mL
20 mM	0.1350 mL	0.6750 mL	1.3500 mL	6.7502 mL
50 mM	0.0540 mL	0.2700 mL	0.5400 mL	2.7001 mL
100 mM	0.0270 mL	0.1350 mL	0.2700 mL	1.3500 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Homocarbonyltopsentin