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ZYF0033

Name: ZYF0033
Brand: TargetMol
SKU: T62927
Price: 142 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T62927Cas No. 2380300-79-6

Alias ZYF 0033, HPK1-IN-22

ZYF0033 is an orally effective small molecule inhibitor of hematopoietic progenitor kinase 1 (HPK1) that inhibits the phosphorylation of MBP proteins.HPK1-IN-22 promotes anticancer immune responses by decreasing the phosphorylation of SLP76 (serine 76), and has the potential to inhibit tumor growth and mediate immune responses.

ZYF0033

🥰Excellent

Catalog No. T62927Alias ZYF 0033, HPK1-IN-22Cas No. 2380300-79-6

Pack Size	Price	Availability
2 mg	$142	In Stock
5 mg	$266	In Stock
25 mg	$1,240	In Stock
50 mg	$1,620	In Stock
100 mg	$2,500	In Stock

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	ZYF0033 is an orally effective small molecule inhibitor of hematopoietic progenitor kinase 1 (HPK1) that inhibits the phosphorylation of MBP proteins.HPK1-IN-22 promotes anticancer immune responses by decreasing the phosphorylation of SLP76 (serine 76), and has the potential to inhibit tumor growth and mediate immune responses.
In vitro	ZYF0033 (HPK1-IN-22) (100 nM, 24 h) reduces the phosphorylation of SLP76 (serine 376) in T cells, leading to HPK1 inhibition and increasing the proliferation of CD4+ and CD8+ T cells and the secretion of IFN-γ. [1]
Alias	ZYF 0033, HPK1-IN-22

Chemical Properties

Molecular Weight	462.61
Formula	C₂₆H₃₀N₄O₂S
Cas No.	2380300-79-6
Smiles	OC(C#CC1=CC=CC(=C1)COC=2C=C(C=NC2N)C=3SC(=NC3)C4CCN(C)CC4)(C)C

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 80 mg/mL (172.93 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1616 mL	10.8082 mL	21.6165 mL	108.0824 mL
5 mM	0.4323 mL	2.1616 mL	4.3233 mL	21.6165 mL
10 mM	0.2162 mL	1.0808 mL	2.1616 mL	10.8082 mL
20 mM	0.1081 mL	0.5404 mL	1.0808 mL	5.4041 mL
50 mM	0.0432 mL	0.2162 mL	0.4323 mL	2.1616 mL
100 mM	0.0216 mL	0.1081 mL	0.2162 mL	1.0808 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc