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Hydroxystilbamidine bis(methanesulfonate)

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Hydroxystilbamidine bis(methanesulfonate)

Catalog No. T19014Cas No. 223769-64-0

Hydroxystilbamidine bis(methanesulfonate) is a dye capable of binding to both DNA and RNA. It also is a potent inhibitor of cellular ribonucleases.

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Pack Size	Price	Availability	Quantity
10 mg	$488	35 days

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Product Introduction

Bioactivity

Description	Hydroxystilbamidine bis(methanesulfonate) is a dye capable of binding to both DNA and RNA. It also is a potent inhibitor of cellular ribonucleases.
In vitro	It is found that the trypanocidal dye Hydroxystilbamidine bis(methanesulfonate) permits the recovery of mRNA after polysome released with Nonidet P-40 (NP-40). Sucrose gradient analysis of detergent-lysed postnuclear supernates is used to analyze the size distribution of NP-40-released polysomes [1].
In vivo	Hydroxystilbamidine bis(methanesulfonate) effectively inhibits the plaque-forming cell (PFC) response when administered prior to sheep erythrocytes (SRBC) stimulation. It reduces the plaque formation in treated mice, leading to a significant decrease in PFC levels. However, the suppressive effect diminishes over time, with PFC counts in both Hydroxystilbamidine bis(methanesulfonate)-treated and control groups reverting to baseline levels by day 14 [2].

Chemical Properties

Molecular Weight	472.53
Formula	C18H24N4O7S2
Cas No.	223769-64-0

Storage & Solubility Information

Storage

keep away from direct sunlight|Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Hydroxystilbamidine bis(methanesulfonate)