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I-SAP is a high affinity TP receptor antagonist. At physiologic pH, I-SAP produces platelet shape change, but not aggregation, with an EC50 value of 9.7 nM. I-SAP binds to human platelets with the maximum binding obtained between pH 6.5 and pH 7.4. In washed human platelets, the Kd for I-SAP is 468 pM at pH 7.4 and 490 pM at pH 6.5.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
100 μg | $183 | 35 days | |
500 μg | $793 | 35 days | |
1 mg | $1,430 | 35 days |
Description | I-SAP is a high affinity TP receptor antagonist. At physiologic pH, I-SAP produces platelet shape change, but not aggregation, with an EC50 value of 9.7 nM. I-SAP binds to human platelets with the maximum binding obtained between pH 6.5 and pH 7.4. In washed human platelets, the Kd for I-SAP is 468 pM at pH 7.4 and 490 pM at pH 6.5. |
Molecular Weight | 531.45 |
Formula | C22H30INO4S |
Cas No. | 133538-58-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO: >25 mg/mL (from Pinane TXA2) Ethanol: >100 mg/mL (from Pinane TXA2) DMF: >50 mg/mL (from Pinane TXA2) PBS (pH 7.2): >100 μ g/mL (from Pinane TXA2) |
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