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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $3,920 | 10-14 weeks | |
50 mg | $5,180 | 10-14 weeks | |
100 mg | $7,300 | 10-14 weeks |
Description | IACS-8779 is a potent STING agonist that efficiently stimulates interferon gene activity and exhibits strong systemic antitumor effects. |
In vivo | Mice bilaterally implanted with B16-Ova tumors received intra-tumoral injections of IACS-8779 (compound 1a) at a 10 μg dose solely on one flank at intervals of three days, specifically on days 6, 9, and 12 post-implantation. While IACS-8779 demonstrated comparable antitumor efficacy on the treated flank, it elicited superior tumor regression on the untreated, contralateral flank. This indicates a stronger systemic immune response by IACS-8779 than that achieved by benchmark analogs. Furthermore, treatment with IACS-8779 resulted in a higher rate of mice being cured of tumors on both flanks, surpassing the outcomes observed with benchmark treatments. |
Molecular Weight | 689.55 |
Formula | C21H25N9O10P2S2 |
Cas No. | 2243079-26-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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