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Ianalumab

Name: Ianalumab
Brand: TargetMol
SKU: T77370
Price: 222 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T77370Cas No. 1929549-92-7

Alias VAY-736

Ianalumab (VAY-736) is a decarboxylated humanized antibody against BAFF-R that inhibits the interaction between BAFF and BAFF-R, blocking BAFF-mediated apoptosis protection. Ianalumab exhibits antibody-dependent cytotoxicity (ADCC) and activates effector cells via the immune receptor tyrosine activation motif (ITAM).

Ianalumab

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Purity: 100% (SEC-HPLC)

Catalog No. T77370Alias VAY-736Cas No. 1929549-92-7

Pack Size	Price	Availability
1 mg	$222	In Stock
5 mg	$553	In Stock
10 mg	$796	In Stock
25 mg	$1,220	In Stock
50 mg	$1,650	In Stock
100 mg	$2,220	In Stock

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Concentration:5.35 mg/mL

Purity:100% (SEC-HPLC)

Resource Download

COA SDS-PAGE SEC-HPLC Instruction Manual of Inhibitory Antibody

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	Ianalumab (VAY-736) is a decarboxylated humanized antibody against BAFF-R that inhibits the interaction between BAFF and BAFF-R, blocking BAFF-mediated apoptosis protection. Ianalumab exhibits antibody-dependent cytotoxicity (ADCC) and activates effector cells via the immune receptor tyrosine activation motif (ITAM).
In vitro	Ianalumab (0.1 μg/mL; 72 h) demonstrates significant antibody-dependent cell-mediated cytotoxicity (ADCC) against natural killer cells in chronic lymphocytic leukemia (CLL), enhancing cytokine production[1].
In vivo	Ianalumab (total dose: 100 mg/kg; once a week; for 2 weeks) increases the survival rate in a mouse model of chronic lymphocytic leukemia (CLL)[1]. Ianalumab (10 mg/kg; once a week; for 6 weeks), when modulated with Ibrutinib, demonstrates enhanced functionality of NK cells[1].
Alias	VAY-736

Chemical Properties

Molecular Weight	146.44 kDa
Cas No.	1929549-92-7

Storage & Solubility Information

Storage

store at low temperature | store at -80°C | Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

VAY736VAY 736Ianalumab